Ethyl Acetate → HCID 90426016, 화합물
반응식
Cl[CH2:2][CH2:3][NH:4][C:5]([NH:7][C@@H:8]([CH3:12])[CH2:9][O:10][CH3:11])=[O:6].[H-].[Na+].CCOC(C)=O>C1COCC1>[CH3:11][O:10][CH2:9][C@H:8]([N:7]1[CH2:2][CH2:3][NH:4][C:5]1=[O:6])[CH3:12]참가 물질
5
실험 절차
A −20° C. solution of (S)-1-(2-chloroethyl)-3-(1-methoxypropan-2-yl)urea (393 mg, 2.019 mmol) in THF (10 mL) was treated portion-wise with NaH (60% in mineral oil, 178 mg, 4.44 mmol), warmed to RT and stirred overnight. The mixture was treated with EtOAc, washed with water, then brine, dried over Na2SO4 and concentrated to dryness to afford crude (R)-1-(1-methoxypropan-2-yl)imidazolidin-2-one (100% yield assumed) which was used without further purification. MS (ESI) m/z: 159.1 (M+H+).
후처리
- washwashed with water
- dry with materialbrine, dried over Na2SO4
- concentrationconcentrated to dryness
출처 및 근거
- ORD 기록
- ord-093c4df1356c406693abfacaf3fa21fc
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09133183B2
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