3-Chlorobenzoic Acid → (1,1'-Biphenyl)-3-carboxylic acid

HRID 227921

반응식

HRID 227921 반응식
Cl[C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].[C:11]1(B(O)O)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C1(P(C2CCCCC2)C2C=CC=CC=2C2C(OC)=CC=C(S([O-])(=O)=O)C=2OC)CCCCC1.[Na+].C([O-])([O-])=O.[K+].[K+]>CC([O-])=O.CC([O-])=O.[Pd+2]>[C:2]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([OH:7])=[O:6])[CH:3]=1

참가 물질

6

반응물 4

HCID 4473-Chlorobenzoic AcidHCID 11430Potassium CarbonateHCID 66827Phenylboronic AcidHCID 23677046Sodium 2'-(dicyclohexylphosphino)-2,6-dimethoxybiphenyl-3-sulfonate

생성물 1

HCID 12854(1,1'-Biphenyl)-3-carboxylic acid

시약·촉매·용매 1

HCID 167845palladium(II) acetate촉매

실험 절차

The general procedure described in Example 3 was used with 3-chlorobenzoic acid (157 mg, 1.00 mmol), phenylboronic acid (145 mg, 1.20 mmol), Pd(OAc)2 (4.5 mg, 0.020 mmol, 2 mol %), sodium 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl-3′-sulfonate (20.0 mg, 0.040 mmol, 4 mol %), K2CO3 (345 mg, 2.50 mmol), solvent (see FIG. 5) (2.0 mL), 14 h, temperature. The conversion and yield were determined using 1H NMR.

후처리

  1. customThe conversion and yield

출처 및 근거

ORD 기록
ord-fa0ba15a14634939907da955358fc750
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560596B2

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