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1-(Methylamino)adamantane → HCID 178434554, 화합물

HRID 2279615
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HRID 2279615 반응식
F[P-](F)(F)(F)(F)F.[N:8]1(O[P+](N(C)C)(N(C)C)N(C)C)[C:12]2C=CC=CC=2N=N1.[C:28]12(NC)[CH2:37][CH:32]3[CH2:33][CH:34]([CH2:36][CH:30]([CH2:31]3)[CH2:29]1)[CH2:35]2.[CH3:40][C:41]1[C:45]([C:46]([OH:48])=O)=[CH:44][NH:43][N:42]=1.CCN(C(C)C)C(C)C>C(Cl)Cl>[C:28]12([CH2:12][NH:8][C:46]([C:45]3[C:41]([CH3:40])=[N:42][NH:43][CH:44]=3)=[O:48])[CH2:29][CH:30]3[CH2:31][CH:32]([CH2:33][CH:34]([CH2:36]3)[CH2:35]1)[CH2:37]2
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참가 물질

6

반응물 4

HCID 194761-(Methylamino)adamantaneHCID 81531DiisopropylethylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 5576005-methyl-1H-pyrazole-4-carboxylic acid

생성물 1

HCID 178434554HCID 178434554, 화합물

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매

실험 절차

BOP (3.53 g, 8 mmol) is added to a solution of adamantan-1-yl-methylamine (1.32 g, 8 mmol), 3-methyl-1H-pyrazole-4-carboxylic acid (1 g, 7 mmol) and DIEA (2.6 g, 20 mmol) in DCM (25 mL). The solution is stirred overnight and evaporated, and then partitioned between EtOAc and saturated aqueous sodium bicarbonate. The organic layer is washed with brine, dried and evaporated. The residue is triturated with DCM and air-dried to give the title compound.

후처리

  1. customevaporated
  2. custompartitioned between EtOAc and saturated aqueous sodium bicarbonate
  3. washThe organic layer is washed with brine
  4. customdried
  5. customevaporated
  6. customThe residue is triturated with DCM
  7. customair-dried

출처 및 근거

ORD 기록
ord-a8d360d9c74a4688bf1359ace9e043ce
출처 데이터셋
uspto-grants-2015_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09133204B2

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