Water → HCID 59579909, 화합물
반응식
[OH-].[Na+].[Cl:3][C:4]1[N:8]([C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:7]=[CH:6][C:5]=1[C:15]([O:17]CC)=[O:16].O>CCO>[Cl:3][C:4]1[N:8]([C:9]2[N:14]=[CH:13][CH:12]=[CH:11][N:10]=2)[N:7]=[CH:6][C:5]=1[C:15]([OH:17])=[O:16]참가 물질
5
실험 절차
A 1 N aqueous sodium hydroxide solution (2.0 mL) is added to a suspension of ethyl 5-chloro-1-pyrimidin-2-yl-1H-pyrazole-4-carboxylate (250 mg, 1.11 mmol) in 5.0 mL of EtOH. The reaction mixture is stirred at RT for 1 h. Water is added, and the solution is washed with EtOAc. The aqueous layer is cooled to 0° C. and acidified to pH=2-3 with conc. HCl. The precipitated solid is collected by vacuum filtration and dried in vacuo to give the title compound as a white solid.
후처리
- washthe solution is washed with EtOAc
- temperatureThe aqueous layer is cooled to 0° C.
- filtrationThe precipitated solid is collected by vacuum filtration
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-d0bcc064cd7d40eabdbff48f7a539541
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09133204B2
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