Sodium Hydroxide → 5-Benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid

HRID 2279642노트

반응식

HRID 2279642 반응식
[OH-].[Na+].C[O:4][C:5]([C:7]1[C:8]([CH3:20])=[N:9][N:10]([CH3:19])[C:11]=1[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:6]>CO>[CH2:12]([C:11]1[N:10]([CH3:19])[N:9]=[C:8]([CH3:20])[C:7]=1[C:5]([OH:6])=[O:4])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 154462275-benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid methyl ester

생성물 1

HCID 595799845-Benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

NaOH (10 N, 7 mL) is added to a solution of 5-benzyl-1,3-dimethyl-1H-pyrazole-4-carboxylic acid methyl ester (680 mg, 2.78 mmol) in MeOH (10 mL) at RT. The mixture is heated to 50° C. for 4 h. The solvent is removed to dryness. H2O is added and pH is adjusted to 5 using aq. HCl. The solid is filtered and dried to give the title compound.

후처리

  1. customThe solvent is removed to dryness
  2. additionH2O is added
  3. filtrationThe solid is filtered
  4. customdried

출처 및 근거

ORD 기록
ord-addbbf4343454f61b3a7044fb462cd9f
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133204B2

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