Sodium Hydroxide → HCID 59580006, 화합물

HRID 2279651노트

반응식

HRID 2279651 반응식
C([O:3][C:4]([C:6]1[S:10][C:9]([C:11]2[N:16]=[CH:15][CH:14]=[CH:13][N:12]=2)=[N:8][C:7]=1[C:17]([F:20])([F:19])[F:18])=[O:5])C.[OH-].[Na+]>CO.O>[N:16]1[CH:15]=[CH:14][CH:13]=[N:12][C:11]=1[C:9]1[S:10][C:6]([C:4]([OH:5])=[O:3])=[C:7]([C:17]([F:19])([F:20])[F:18])[N:8]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 59579876HCID 59579876, 화합물

생성물 1

HCID 59580006HCID 59580006, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

A mixture of 2-pyrimidin-2-yl-4-trifluoromethyl-thiazole-5-carboxylic acid ethyl ester (1.6 g) and sodium hydroxide (1.2 g) in MeOH (10 mL) and water (3 mL) is heated at 50° C. with stirring for 30 min, cooled and evaporated. The residue is acidified with citric acid solution and extracted with EtOAc six times. The combined extracts are washed once with brine, dried over Na2SO4 and concentrated to give the title compound as a solid.

후처리

  1. temperaturecooled
  2. customevaporated
  3. extractionextracted with EtOAc six times
  4. washThe combined extracts are washed once with brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-02dfca3419d748ae88c90c15391661e5
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09133204B2

반응 노트

불러오는 중…