Sodium Hydroxide → (Pyrimidin-4-yl)acetic acid

HRID 2280166노트

반응식

HRID 2280166 반응식
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([O:10]CC)=[O:9])=[N:3][CH:2]=1.[OH-].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([OH:10])=[O:9])=[N:3][CH:2]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 20295406Ethyl 2-(pyrimidin-4-yl)acetate

생성물 1

HCID 21486925(Pyrimidin-4-yl)acetic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of ethyl 2-(pyrimidin-4-yl)acetate (Example 33b, 450 mg. 2.71 mmol) in ethanol (5 mL) was added 2N NaOH (2 mL) at room temperature under nitrogen. The reaction mixture was stirred at room temperature under nitrogen for 24 hours, concentrated under reduced pressure and suspended in ethanol. The solid was removed by vacuum filtration, and the filtrate was concentrated under reduced pressure, triturated with ethanol, concentrated again and carried onto the next step without further purification. MS139 (MH+).

후처리

  1. concentrationconcentrated under reduced pressure
  2. customThe solid was removed by vacuum filtration
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customtriturated with ethanol
  5. concentrationconcentrated again
  6. customcarried onto the next step without further purification

출처 및 근거

ORD 기록
ord-07c2ef4d898640b8b055a75f93049263
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09138013B2

반응 노트

불러오는 중…