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Lithium Hydroxide → (S)-2-(6-((4'-((1-(cyclopropanecarbonyl)azetidin-3-yl)oxy)-2',6'-dimethylbiphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid

HRID 2280665
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HRID 2280665 반응식
[CH:1]1([C:4]([N:6]2[CH2:9][CH:8]([O:10][C:11]3[CH:16]=[C:15]([CH3:17])[C:14]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][O:25][C:26]5[CH:39]=[CH:38][C:29]6[C@H:30]([CH2:33][C:34]([O:36]C)=[O:35])[CH2:31][O:32][C:28]=6[CH:27]=5)[CH:19]=4)=[C:13]([CH3:40])[CH:12]=3)[CH2:7]2)=[O:5])[CH2:3][CH2:2]1.[OH-].[Li+]>CO>[CH:1]1([C:4]([N:6]2[CH2:9][CH:8]([O:10][C:11]3[CH:16]=[C:15]([CH3:17])[C:14]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24][O:25][C:26]5[CH:39]=[CH:38][C:29]6[C@H:30]([CH2:33][C:34]([OH:36])=[O:35])[CH2:31][O:32][C:28]=6[CH:27]=5)[CH:19]=4)=[C:13]([CH3:40])[CH:12]=3)[CH2:7]2)=[O:5])[CH2:3][CH2:2]1
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참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 117699344(S)-methyl 2-(6-((4'-((1-(cyclopropanecarbonyl)azetidin-3-yl)oxy)-2',6'-dimethylbiphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetate

생성물 1

HCID 71657093(S)-2-(6-((4'-((1-(cyclopropanecarbonyl)azetidin-3-yl)oxy)-2',6'-dimethylbiphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid수율 44%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The crude (S)-methyl 2-(6-((4′-((1-(cyclopropanecarbonyl)azetidin-3-yl)oxy)-2′,6′-dimethylbiphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetate 15b (46 mg, 0.09 mmol) was dissolved in 3 mL of methanol, followed by addition of 1M aqueous lithium hydroxide solution (0.5 mL, 0.50 mmol). The reaction solution was stirred for 3 hours. The resulting solution was concentrated under reduced pressure, 1M hydrochloric acid was added dropwise to adjust the pH to 3, 3 mL of water were added, and then the solution was extracted with ethyl acetate (20 mL×2). The combined organic extracts were washed with saturated sodium chloride solution (30 mL), dried with anhydrous magnesium sulphate, and filtered. The filtrate was concentrated under reduced pressure to obtain the title compound (S)-2-(6-((4′-((1-(cyclopropanecarbonyl)azetidin-3-yl)oxy)-2′,6′-dimethylbiphenyl-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid 15 (20 mg, yield 44.0%) as a yellow solid.

후처리

  1. concentrationThe resulting solution was concentrated under reduced pressure, 1M hydrochloric acid
  2. additionwas added dropwise
  3. additionwere added
  4. extractionthe solution was extracted with ethyl acetate (20 mL×2)
  5. washThe combined organic extracts were washed with saturated sodium chloride solution (30 mL)
  6. dry with materialdried with anhydrous magnesium sulphate
  7. filtrationfiltered
  8. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f17bf3614d1a4dd893b3ef64a2b1382b
출처 데이터셋
uspto-grants-2015_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09139548B2

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