Acetyl chloride → N-cylcohexyl-N-(2-furan-2-yl-6-trifluoromethylimidazo[1,2-a]pyridin-3-yl)-acetamide

HRID 22811

반응식

HRID 22811 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][N:3]=1.[CH:12]1([N+:18]#[C-:19])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1.[CH:20](=O)[C:21]1[O:25][CH:24]=[CH:23][CH:22]=1.[C:27](Cl)(=[O:29])[CH3:28]>Cl(O)(=O)(=O)=O>[CH:12]1([N:18]([C:19]2[N:3]3[CH:4]=[C:5]([C:8]([F:9])([F:11])[F:10])[CH:6]=[CH:7][C:2]3=[N:1][C:20]=2[C:21]2[O:25][CH:24]=[CH:23][CH:22]=2)[C:27](=[O:29])[CH3:28])[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1

참가 물질

6

반응물 4

HCID 6367Acetyl chlorideHCID 7362FurfuralHCID 79129Cyclohexyl isocyanideHCID 7358622-Amino-5-(trifluoromethyl)pyridine

생성물 1

HCID 9865235N-cylcohexyl-N-(2-furan-2-yl-6-trifluoromethylimidazo[1,2-a]pyridin-3-yl)-acetamide

시약·촉매·용매 1

HCID 24247Perchloric Acid용매

실험 절차

Compound (34) was prepared from 1.0 ml of 2-amino-5-trifluoromethylpyridine solution (0.1 M, DCM), 0.575 ml of cyclohexyl isocyanide solution (0.2 M, DCM), 0.500 ml of furfural solution (0.3 M, DCM), and 10 μl of perchloric acid (w=20%), and reaction with acetyl chloride. Excess acetyl chloride was removed under reduced pressure.

후처리

  1. customExcess acetyl chloride was removed under reduced pressure

출처 및 근거

ORD 기록
ord-d387b66b0d28469785ad0fe97ff93600
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849642B2

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