Phosphorus oxychloride → 3-(Propan-2-yl)benzonitrile

HRID 2281279

반응식

HRID 2281279 반응식
[CH:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([NH2:9])=O)([CH3:3])[CH3:2].O=P(Cl)(Cl)Cl>>[CH:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]#[N:9])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 2579543-(Propan-2-yl)benzamide

생성물 1

HCID 2584403-(Propan-2-yl)benzonitrile수율 80.4%

실험 절차

A solution of the above amide (4.20 g, 25.7 mmol) in POCl3 (36.0 g, 236 mmol) was stirred at 80° C. for 18 h. The solution was concentrated and the residue was poured into water (100 mL). The mixture was exacted with EtOAc. The organic layers were combined, washed by brine, dried over Na2SO4 and concentrated to give 3-isopropyl-benzonitrile (3.00 g, 80%).

후처리

  1. concentrationThe solution was concentrated
  2. additionthe residue was poured into water (100 mL)
  3. washwashed by brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b40b6c01aa504cb085c13f455ac6611a
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09139580B2

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