Chlorotrimethylsilane → HCID 44467815, 화합물

HRID 2281426노트

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HRID 2281426 반응식
Cl[C:2]1[N:3]=[C:4]([NH:12][CH:13]2[CH2:16][CH2:15][CH2:14]2)[C:5]2[C:10]([Cl:11])=[CH:9][NH:8][C:6]=2[N:7]=1.[NH2:17][C:18]1[CH:26]=[C:25]2[C:21]([CH:22]=[N:23][NH:24]2)=[CH:20][CH:19]=1.C[Si](Cl)(C)C>C(O)CCC>[Cl:11][C:10]1[C:5]2[C:4]([NH:12][CH:13]3[CH2:16][CH2:15][CH2:14]3)=[N:3][C:2]([NH:17][C:18]3[CH:26]=[C:25]4[C:21]([CH:22]=[N:23][NH:24]4)=[CH:20][CH:19]=3)=[N:7][C:6]=2[NH:8][CH:9]=1

참가 물질

5

반응물 3

HCID 6397ChlorotrimethylsilaneHCID 814231H-Indazol-6-amineHCID 57990315HCID 57990315, 화합물

생성물 1

HCID 44467815HCID 44467815, 화합물수율 25.4%

시약·촉매·용매 1

HCID 2631-Butanol용매

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온도
116 °C

실험 절차

A mixture of 2,5-dichloro-N-cyclobutyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (23 mg, 0.089 mmol), 6-aminoindazole (40 mg, 0.30 mmol) and TMSCl (0.040 mL, 0.32 mmol) in nBuOH (2 mL) was stirred at 116° C. for 18 h. It was then concentrated in vacuo. The residue was purified by HPLC to give the titled compound (8 mg). MS 354.0, 356.0 (M+H, Cl pattern); UV 201.4, 246.2, 307.9 nm.

후처리

  1. concentrationIt was then concentrated in vacuo
  2. customThe residue was purified by HPLC

출처 및 근거

ORD 기록
ord-01436ecd85484756b566694eda463734
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09139581B2

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