Chlorotrimethylsilane → HCID 44468023, 화합물

HRID 2281515노트

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HRID 2281515 반응식
Cl[C:2]1[N:3]=[C:4]([NH:28]C2CC2)[C:5]2[C:10]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)=[CH:9][N:8](S(C3C=CC(C)=CC=3)(=O)=O)[C:6]=2[N:7]=1.[NH2:32][C:33]1[CH:34]=[C:35]2[C:40](=[CH:41][CH:42]=1)[N:39]([CH3:43])[C:38](=[O:44])[CH2:37][CH2:36]2.C[Si](Cl)(C)C>C(O)CCC>[NH2:28][C:4]1[C:5]2[C:10]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)=[CH:9][NH:8][C:6]=2[N:7]=[C:2]([NH:32][C:33]2[CH:34]=[C:35]3[C:40](=[CH:41][CH:42]=2)[N:39]([CH3:43])[C:38](=[O:44])[CH2:37][CH2:36]3)[N:3]=1

참가 물질

5

반응물 3

HCID 6397ChlorotrimethylsilaneHCID 218777566-Amino-1-methyl-3,4-dihydroquinolin-2(1H)-oneHCID 57990376HCID 57990376, 화합물

생성물 1

HCID 44468023HCID 44468023, 화합물

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

A solution of 2-chloro-N-cyclopropyl-5-(4-fluorophenyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (76 mg, 0.17 mmol), 6-amino-1-methyl-3,4-dihydroquinolin-2(1H)-one (60 mg, 0.34 mmol) and trimethylsilyl chloride (0.200 mL, 1.58 mmol) in nBuOH (2 mL) was stirred at 135° C. for 20 h. It was concentrated in vacuo. The residue was purified by HPLC to give the titled compound. MS 403.4 (M+H); UV 205.3, 293.4 nm.

후처리

  1. concentrationIt was concentrated in vacuo
  2. customThe residue was purified by HPLC

출처 및 근거

ORD 기록
ord-2470867a160e40acb0566b12503be687
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09139581B2

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