3-Isopropoxypropylamine → 3-(3-Isopropoxypropylsulfamoyl)benzoic acid

HRID 2281617노트

반응식

HRID 2281617 반응식
[CH:1]([O:4][CH2:5][CH2:6][CH2:7][NH2:8])([CH3:3])[CH3:2].C(N(CC)C(C)C)(C)C.C[C:19]1[C:27]([S:28](Cl)(=[O:30])=[O:29])=[CH:26][CH:25]=[CH:24][C:20]=1[C:21]([OH:23])=[O:22]>C1COCC1>[CH:1]([O:4][CH2:5][CH2:6][CH2:7][NH:8][S:28]([C:27]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21]([OH:23])=[O:22])(=[O:30])=[O:29])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 761943-IsopropoxypropylamineHCID 81531DiisopropylethylamineHCID 543955313-(Chlorosulfonyl)-2-methylbenzoic acid

생성물 1

HCID 670865933-(3-Isopropoxypropylsulfamoyl)benzoic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

3-Isopropoxypropylamine (1.1 eq.) is dissolved in THF with stirring at room temperature. N,N-diisopropylethylamine (1 eq.) is added followed by methyl 3-(chlorosulfonyl)benzoic acid (1 eq.). The reaction mixture is stirred at room temperature for 2 hours before the solvent is evaporated in vacuo to yield the crude titled product.

후처리

  1. stirringThe reaction mixture is stirred at room temperature for 2 hours before the solvent
  2. customis evaporated in vacuo

출처 및 근거

ORD 기록
ord-fc95b26bf3c24298aa05ecffb1872735
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09139586B2

반응 노트

불러오는 중…