Hydrochloric Acid → Methyl 3-chloro-4-hydroxy-5-methoxybenzoate
반응식
[Cl:1][C:2]1[C:3]([OH:13])=[C:4]([O:11][CH3:12])[CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].Cl.[CH3:15]O>>[CH3:15][O:8][C:7](=[O:9])[C:6]1[CH:5]=[C:4]([O:11][CH3:12])[C:3]([OH:13])=[C:2]([Cl:1])[CH:10]=1참가 물질
4
실험 절차
A mixture of 5-chlorovanillic acid (5.0 g, 24.6 mmol) and conc. HCl (5 ml) in MeOH (100 ml) is heated at reflux for 48 hours. The solvent is removed in vacuo and water is added to the residue to yield a white precipitate, which is collected by filtration, washed with water, and then dissolved in Et2O. The solution is dried (Na2SO4) and the solvent removed in vacuo to yield 3-Chloro-4-hydroxy-5-methoxy-benzoic acid methyl ester as a white solid.
후처리
- temperatureis heated
- temperatureat reflux for 48 hours
- customThe solvent is removed in vacuo and water
- additionis added to the residue
- customto yield a white precipitate, which
- filtrationis collected by filtration
- washwashed with water
- dissolutiondissolved in Et2O
- dry with materialThe solution is dried (Na2SO4)
- customthe solvent removed in vacuo
출처 및 근거
- ORD 기록
- ord-2c8e8947864b433182c7571b797dd203
- 출처 데이터셋
- uspto-grants-2015_09
- 특허 번호
- US09139586B2
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