Methane → 3-(Ethylhydroxyphosphinyl)propionic acid sodium salt

HRID 2282075노트

반응식

HRID 2282075 반응식
[CH2:1]([P:3]([CH2:6][CH2:7][CH2:8][OH:9])(=[O:5])[OH:4])[CH3:2].[OH-:10].[Na+:11].C>O>[Na+:11].[CH2:1]([P:3]([OH:4])([CH2:6][CH2:7][C:8]([O-:10])=[O:9])=[O:5])[CH3:2]

참가 물질

5

반응물 3

HCID 297MethaneHCID 14798Sodium Hydroxide2회HCID 86656674Ethyl-3-hydroxypropylphosphinic acid

생성물 1

HCID 1317314203-(Ethylhydroxyphosphinyl)propionic acid sodium salt수율 93%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
70 °C

실험 절차

15.2 g (0.1 mol) of ethyl-3-hydroxypropylphosphinic acid (produced as in Example 5) are dissolved in 150 ml of water and adjusted to pH 9 with 2N NaOH solution. Then, 0.45 g of charcoal with 5% Pt and 1% Bi is added, the suspension is heated to 70° C. and air is passed through the suspension at 10 l/h. All the while, the pH of the suspension is maintained at pH=9 by adding 2N NaOH in solution. After the reaction is ended, the reaction solution is filtered to remove the catalyst, the filter residue is washed and the water is distilled off in vacuo to obtain 19.5 g (93% of theory) of 3-(ethylhydroxyphosphinyl)propionic acid sodium salt as colorless solid.

후처리

  1. temperatureAll the while, the pH of the suspension is maintained at pH=9
  2. filtrationthe reaction solution is filtered
  3. customto remove the catalyst
  4. washthe filter residue is washed
  5. distillationthe water is distilled off in vacuo

출처 및 근거

ORD 기록
ord-18c904636c53462ca28f2beb6542408a
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09139714B2

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