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Hydrochloric Acid → (2R,3R)-3-methoxy-2-methyl-N-(2-phenylethyl)-3-[(2S)-pyrrolidin-2-yl] propanamide, hydrochloride salt

HRID 2282815
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HRID 2282815 반응식
[CH3:1][O:2][C@@H:3]([C@@H:17]1[CH2:21][CH2:20][CH2:19][N:18]1C(OC(C)(C)C)=O)[C@@H:4]([CH3:16])[C:5](=[O:15])[NH:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[ClH:29]>O1CCOCC1.CO>[ClH:29].[CH3:1][O:2][C@@H:3]([C@@H:17]1[CH2:21][CH2:20][CH2:19][NH:18]1)[C@@H:4]([CH3:16])[C:5]([NH:6][CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)=[O:15]
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참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 86685721tert-butyl (2S)-2-{(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl}pyrrolidine-1-carboxylate

생성물 1

HCID 131731845(2R,3R)-3-methoxy-2-methyl-N-(2-phenylethyl)-3-[(2S)-pyrrolidin-2-yl] propanamide, hydrochloride salt

시약·촉매·용매 2

HCID 887Methanol용매HCID 312751,4-Dioxane용매2회

실험 절차

To #20 (7.00 g, 17.9 mmol, 1 eq.) in dioxane (50 mL, 0.36 M) and methanol (2 mL) was added a 4 M solution of hydrochloric acid in dioxane (20 mL, 80 mmol, 4.4 eq.). After stirring for 18 hours, the mixture was concentrated to afford #24 (5.86 g, quantitative) as a gum, which was used without further purification; LC-MS: 292.2 [M+H+], retention time=0.47 minutes.

후처리

  1. concentrationthe mixture was concentrated
  2. customto afford #24 (5.86 g, quantitative) as a gum, which
  3. customwas used without further purification

출처 및 근거

ORD 기록
ord-bc617d31caf54dc697a0f792946b4741
출처 데이터셋
uspto-grants-2015_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09138486B2

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