Diisopropylethylamine → HCID 86685776, 화합물

HRID 2282916노트

반응식

HRID 2282916 반응식
[CH:1]1[C:13]2[CH:12]([CH2:14][O:15][C:16]([NH:18][C:19]([CH3:56])([C:21]([NH:23][C@H:24]([C:28]([N:30]([C@@H:32]([C@@H:52]([CH3:55])[CH2:53][CH3:54])[C@H:33]([O:50][CH3:51])[CH2:34][C:35]([N:37]3[CH2:41][CH2:40][CH2:39][C@H:38]3[C@H:42]([O:48][CH3:49])[C@H:43]([C:45](O)=[O:46])[CH3:44])=[O:36])[CH3:31])=[O:29])[CH:25]([CH3:27])[CH3:26])=[O:22])[CH3:20])=[O:17])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH3:57][C@H:58]1[NH:62][C:61](=[O:63])[NH:60][C@H:59]1[CH2:64][CH2:65][CH2:66][CH2:67][CH2:68][C:69]([NH:71][CH2:72][CH2:73][NH:74][C:75](=[O:85])[C@H:76]([CH2:78][C:79]1[CH:84]=[CH:83][CH:82]=[CH:81][CH:80]=1)[NH2:77])=[O:70].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>CN(C=O)C>[CH:10]1[C:11]2[CH:12]([CH2:14][O:15][C:16]([NH:18][C:19]([CH3:20])([C:21]([NH:23][C@H:24]([C:28]([N:30]([C@@H:32]([C@@H:52]([CH3:55])[CH2:53][CH3:54])[C@H:33]([O:50][CH3:51])[CH2:34][C:35]([N:37]3[CH2:41][CH2:40][CH2:39][C@H:38]3[C@@H:42]([C@@H:43]([CH3:44])[C:45](=[O:46])[NH:77][C@@H:76]([CH2:78][C:79]3[CH:80]=[CH:81][CH:82]=[CH:83][CH:84]=3)[C:75](=[O:85])[NH:74][CH2:73][CH2:72][NH:71][C:69](=[O:70])[CH2:68][CH2:67][CH2:66][CH2:65][CH2:64][C@H:59]3[C@@H:58]([CH3:57])[NH:62][C:61](=[O:63])[NH:60]3)[O:48][CH3:49])=[O:36])[CH3:31])=[O:29])[CH:25]([CH3:27])[CH3:26])=[O:22])[CH3:56])=[O:17])[C:13]3[C:5](=[CH:4][CH:3]=[CH:2][CH:1]=3)[C:6]=2[CH:7]=[CH:8][CH:9]=1

참가 물질

6

반응물 4

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 89573170HCID 89573170, 화합물HCID 89580693HCID 89580693, 화합물

생성물 1

HCID 86685776HCID 86685776, 화합물수율 27.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Following general procedure D using #105 (36.6 mg, 0.047 mmol, 1.0 eq.), #255 (19 mg, 0.047 mmol, 1.0 eq.), HATU (22.4 mg, 0.056 mmol, 1.2 eq.) and Hunig's base (0.025 mL, 0.141 mmol) in 1.5 mL of DMF following by purification (Method J) yielded #256 (15 mg, 27%) as a white solid. LC-MS (Protocol Q1): m/z 1164.8 [M+H+], retention time=0.99 minutes.

후처리

  1. customby purification (Method J)

출처 및 근거

ORD 기록
ord-6d04db738a7b47a89491251dba668d9c
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09138486B2

반응 노트

불러오는 중…