Acetone → 1H-Indole, 2-methyl-4-nitro-

HRID 2283680노트

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HRID 2283680 반응식
[CH3:1][C:2]([CH3:4])=O.C(O[K])(C)(C)C.[N+:11]([C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][CH:20]=1)[NH2:17])([O-:13])=[O:12]>CS(C)=O.C(OCC)(=O)C>[CH3:1][C:2]1[NH:17][C:16]2[C:15]([CH:4]=1)=[C:14]([N+:11]([O-:13])=[O:12])[CH:20]=[CH:19][CH:18]=2

참가 물질

6

반응물 3

HCID 180AcetoneHCID 74233-NitroanilineHCID 178418922HCID 178418922, 화합물

생성물 1

HCID 110951501H-Indole, 2-methyl-4-nitro-

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 8857Ethyl Acetate용매

실험 절차

Acetone (1.0 mL) and tert-butoxy potassium (2.7 g) were added to a solution of 3-nitroaniline (1.38 g) in dimethylsulfoxide (20 ml), and the reaction solution was stirred at room temperature for 3 hours. The reaction solution was diluted with ethyl acetate, and washed successively with an aqueous ammonium chloride solution and a saturated saline solution. After drying over anhydrous sodium sulfate, the solvent was evaporated under vacuum. The residue was purified by column chromatography on silica gel (developing solvent:hexane-ethyl acetate) to obtain 2-methyl-4-nitro-1H-indole.

후처리

  1. washwashed successively with an aqueous ammonium chloride solution
  2. dry with materialAfter drying over anhydrous sodium sulfate
  3. customthe solvent was evaporated under vacuum
  4. customThe residue was purified by column chromatography on silica gel (developing solvent:hexane-ethyl acetate)

출처 및 근거

ORD 기록
ord-e2ecb262ccc14118a3c587db2b791875
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09145414B2

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