Phosphorus oxychloride → 1,5-diethyl-1H-pyrazole-3-carbonitrile

반응식

[CH2:1]([N:3]1[C:7]([CH2:8][CH3:9])=[CH:6][C:5]([C:10]([NH2:12])=O)=[N:4]1)[CH3:2].P(Cl)(Cl)(Cl)=O>>[CH2:1]([N:3]1[C:7]([CH2:8][CH3:9])=[CH:6][C:5]([C:10]#[N:12])=[N:4]1)[CH3:2]

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 669585351,5-diethyl-1H-pyrazole-3-carboxamide

생성물 1

HCID 669583001,5-diethyl-1H-pyrazole-3-carbonitrile수율 101.9%

실험 절차

1,5-Diethyl-1H-pyrazole-3-carboxamide (8.3 g, 0.050 mol) was treated with phosphorous oxychloride (35 mL) according to the method described in Part C of Example 7. The reaction was heated for 2.5 hours to provide 7.6 g of 1,5-diethyl-1H-pyrazole-3-carbonitrile as a yellow oil, which was used without purification.

후처리

temperatureThe reaction was heated for 2.5 hours

출처 및 근거

ORD 기록: ord-3fe8159fd0af4a5aae9905aaad922811
출처 데이터셋: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09145410B2

반응 노트

불러오는 중…