Ammonia → HCID 58497086, 화합물

HRID 2283937노트

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HRID 2283937 반응식
[Cl:1][C:2]1[C:7]([CH2:8][CH3:9])=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[NH3:11]>C(O)CCC>[Cl:1][C:2]1[N:3]=[CH:4][N:5]=[C:6]([NH2:11])[C:7]=1[CH2:8][CH3:9]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 218284324,6-Dichloro-5-ethylpyrimidine

생성물 1

HCID 58497086HCID 58497086, 화합물수율 55%

시약·촉매·용매 1

HCID 2631-Butanol용매

반응 조건

온도
100 °C

실험 절차

To a mixture of 4,6-Dichloro-5-ethylpyrimidine (22.5 g, 0.12 mol) in 1-butanol (70 mL) in a 1L glass pressure tube was added aqueous ammonia (26%, 150 mL) at RT. The vessel was sealed and heated to 100° C. for 12 h. The reaction mixture was cooled to RT, the resulted solid was filtered, washed with water (50 mL) and dried under vacuum to afford the titled compound (11.0 g, 55%) as white solid. LCMS: Mass found (M+, 158.0). 1H NMR (400 MHz, CDCl3) 8.02 (s, 1H), 7.10 (bs, 2H), 2.57-2.50 (m, 2H), 1.03-0.99 (m, 3H).

후처리

  1. customThe vessel was sealed
  2. temperatureThe reaction mixture was cooled to RT
  3. filtrationthe resulted solid was filtered
  4. washwashed with water (50 mL)
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-aaad08d38d1f4cea9c598189671b3451
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09145392B2

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