Tert-butyl (3-(2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)propyl)carbamate → 4-(Propylamino)pyrimidine-5-carboxamide

HRID 2284692노트

반응식

HRID 2284692 반응식
C(C1C=CC(N[C:11]2[N:16]=[C:15]([NH:17][CH2:18][CH2:19][CH3:20])[C:14]([C:21]([NH:23]CCCNC(=O)OC(C)(C)C)=[O:22])=[CH:13][N:12]=2)=CC=1)(=O)N>C(Cl)(Cl)Cl.CO.FC(F)(F)C(O)=O>[CH2:18]([NH:17][C:15]1[C:14]([C:21]([NH2:23])=[O:22])=[CH:13][N:12]=[CH:11][N:16]=1)[CH2:19][CH3:20]

참가 물질

5

반응물 1

HCID 90052173Tert-butyl (3-(2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)propyl)carbamate

생성물 1

HCID 1317335334-(Propylamino)pyrimidine-5-carboxamide수율 385.6%

시약·촉매·용매 3

HCID 887Methanol용매HCID 6212Chloroform용매HCID 6422Trifluoroacetic acid용매

실험 절차

To a suspension of tert-butyl (3-(2-((4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamido)propyl)carbamate (D2, 190 mg) in chloroform (8 mL) and methanol (2 mL), trifluoroacetic acid (1 mL) was added at room temperature, and the mixture was stirred at the same temperature for 30 minutes. The solvent was evaporated under reduced pressure to obtain N-(3-aminopropyl)-2-(4-carbamoylphenyl)amino)-4-(propylamino)pyrimidine-5-carboxamide (D3) trifluoroacetate (280 mg).

후처리

  1. additionwas added at room temperature
  2. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-be3a0c69a5e844c48b450b810b856544
출처 데이터셋
uspto-grants-2015_09
특허 번호
US09145415B2

반응 노트

불러오는 중…