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Hydrochloric Acid → 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide hydrochloride

HRID 2284829
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HRID 2284829 반응식
C(OC([N:8]1[CH2:12][CH2:11][S:10][C@H:9]1[C:13]([O:15][C@H:16]([C:27]1[CH:32]=[CH:31][C:30]([O:33][CH:34]([F:36])[F:35])=[C:29]([O:37][CH2:38][CH:39]2[CH2:41][CH2:40]2)[CH:28]=1)[CH2:17][C:18]1[C:23]([Cl:24])=[CH:22][N+:21]([O-:25])=[CH:20][C:19]=1[Cl:26])=[O:14])=O)(C)(C)C.Cl>C(OCC)(=O)C>[ClH:24].[Cl:26][C:19]1[CH:20]=[N+:21]([O-:25])[CH:22]=[C:23]([Cl:24])[C:18]=1[CH2:17][C@@H:16]([C:27]1[CH:32]=[CH:31][C:30]([O:33][CH:34]([F:36])[F:35])=[C:29]([O:37][CH2:38][CH:39]2[CH2:41][CH2:40]2)[CH:28]=1)[O:15][C:13]([C@H:9]1[NH:8][CH2:12][CH2:11][S:10]1)=[O:14]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 867202674-((S)-2-((S)-3-(tert-butoxycarbonyl)thiazolidine-2-carbonyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide

생성물 1

HCID 710925203,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide hydrochloride수율 168.7%

시약·촉매·용매 1

HCID 8857
Ethyl Acetate
용매
2회

실험 절차

4-((S)-2-((S)-3-(tert-butoxycarbonyl)thiazolidine-2-carbonyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)ethyl)-3,5-dichloropyridine 1-oxide (4.22 g, 6.64 mmol) was dissolved in ethyl acetate (10 mL). HCl in ethyl acetate (50 mL, 4.2 M, 210 mmol) was added, and the reaction was stirred at room temperature for 5 minutes. A white precipitate formed, and it was filtered, washed with Ethyl Acetate (2×) and hexane, and dried in a vacuum oven to yield 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-thiazolidine-2-carbonyloxy)ethyl)pyridine 1-oxide hydrochloride (3.19 g, 5.6 mmol, 84%)

후처리

  1. customA white precipitate formed
  2. filtrationit was filtered
  3. washwashed with Ethyl Acetate (2×) and hexane
  4. customdried in a vacuum oven

출처 및 근거

ORD 기록
ord-4ab0b217823b45528d7857ac8986bdca
출처 데이터셋
uspto-grants-2015_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09145409B2

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