Methyl iodide → 2-Amino-6-methylthio-9-(2-hydroxyethoxymethyl)purine

HRID 2285563노트

반응식

HRID 2285563 반응식
[OH:1][CH2:2][CH2:3][O:4][CH2:5][N:6]1[CH:14]=[N:13][C:12]2[C:11](=[S:15])[NH:10][C:9]([NH2:16])=[N:8][C:7]1=2.[CH3:17]I>CO>[NH2:16][C:9]1[N:8]=[C:7]2[C:12]([N:13]=[CH:14][N:6]2[CH2:5][O:4][CH2:3][CH2:2][OH:1])=[C:11]([S:15][CH3:17])[N:10]=1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 178508225HCID 178508225, 화합물

생성물 1

HCID 205176832-Amino-6-methylthio-9-(2-hydroxyethoxymethyl)purine수율 38%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture 9-(2-Hydroxyethoxymethyl)thioguanine (0.7 g), methyl iodide (0.2 ml), Dowex HCO3- resin (1.7 g) and methanol (200 ml) was stirred overnight at room temperature. The resin was removed by filtration, washed with methanol and the combined filtration evaporated, and the residue recrystallized from isopropanol and then from acetone to give 2-amino-6-methylthio-9-(2-hydroxyethoxymethyl)purine, m.p. 188°-191° C. in 38% yield.

후처리

  1. customThe resin was removed by filtration
  2. washwashed with methanol
  3. filtrationthe combined filtration
  4. customevaporated
  5. customthe residue recrystallized from isopropanol

출처 및 근거

ORD 기록
ord-b05f97bf41c54b53ad430bd2dcc816c5
출처 데이터셋
uspto-grants-1982_04
특허 번호
US04323573

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