4-nitro-N-ethylphthalimide → 5-Amino-2-ethylisoindoline-1,3-dione

HRID 2285658

반응식

HRID 2285658 반응식
[CH2:1]([N:3]1[C:7](=[O:8])[C:6]2=[CH:9][C:10]([N+:13]([O-])=O)=[CH:11][CH:12]=[C:5]2[C:4]1=[O:16])[CH3:2]>[Ni].C(O)C>[NH2:13][C:10]1[CH:9]=[C:6]2[C:7](=[O:8])[N:3]([CH2:1][CH3:2])[C:4](=[O:16])[C:5]2=[CH:12][CH:11]=1

참가 물질

4

반응물 1

HCID 8404084-nitro-N-ethylphthalimide

생성물 1

HCID 187040545-Amino-2-ethylisoindoline-1,3-dione

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

N-Ethyl-4-nitrophthalimide (28.0 g.) is hydrogenated in 400 ml. of ethanol and in the presence of Raney nickel catalyst (10 g.) at 100° C. and 1500 psi. pressure. The reaction mixture is filtered to remove the catalyst and the filtrate is concentrated to yield the product, 4-amino-N-ethylphthalimide, which is recrystallized from methanol-water mixture. It melts at 169°-171° C.

후처리

  1. customat 100° C.
  2. filtrationThe reaction mixture is filtered
  3. customto remove the catalyst
  4. concentrationthe filtrate is concentrated

출처 및 근거

ORD 기록
ord-918b8d18a72d404a8b58bec895f52955
출처 데이터셋
uspto-grants-1982_04
특허 번호
US04324719

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