Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine, 1-methyl-4-(4-nitrophenoxy)-4-phenyl- → Piperidine, 4-(p-aminophenoxy)-1-methyl-4-phenyl-
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine, 1-methyl-4-(4-nitrophenoxy)-4-phenyl- | HCID 3060390 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Piperidine, 4-(p-aminophenoxy)-1-methyl-4-phenyl- | HCID 3060392 | 50.3% |
반응 단계
A solution of 1-methyl-4-(4-nitrophenoxy)-4-phenylpiperidine (4.4 g, 14.1 mM) in methanol (250 ml) was hydrogenated at 1 atmosphere and ambient temperature over 5% palladium on charcoal (500 mg) until the theoretical uptake of hydrogen had occurred (about 2 hours). The catalyst was removed by filtration and the solvent evaporated under reduced pressure. Recrystallisation of the residue from IPA gave the title compound (2 g) m.p. 174°-5°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04325953 |
| 출처 데이터셋 | uspto-grants-1982_04 |
| ORD ID | ord-087ae6c0a6d144b4b3419ed8322470da |
| 출처 메모 | uspto-grants-1982_04 |