Ammonium Chloride → (4-Phenylthiophen-2-yl)methanol

HRID 2286190노트

반응식

HRID 2286190 반응식
[C:1]1([C:7]2[CH:8]=[C:9]([CH:12]=[O:13])[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BH4-].[Na+].[NH4+].[Cl-]>C(O)C>[C:1]1([C:7]2[CH:8]=[C:9]([CH2:12][OH:13])[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 4311764Sodium borohydrideHCID 50094674-Phenylthiophene-2-carbaldehyde

생성물 1

HCID 12941349(4-Phenylthiophen-2-yl)methanol수율 96.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A stirred suspension of 4-phenyl-2-thiophenecarboxaldehyde (4.32 g) in absolute ethanol (85 ml) was cooled in an ice-bath and treated with NaBH4 (1.06 g). After 20 min. the mixture was allowed to attain ambient temperature when stirring was continued for 6h. Saturated aqueous NH4Cl (30 ml) was then carefully added to the vigorously stirred mixture, and the resulting suspension extracted with ER (2×200 ml). The combined extracts were dried (Na2SO4 /K2CO3), filtered and evaporated to give the title compound (4.2 g) as crystals, m.p. 112°-113°.

후처리

  1. temperaturewas cooled in an ice-bath
  2. customto attain ambient temperature
  3. waitwas continued for 6h
  4. extractionthe resulting suspension extracted with ER (2×200 ml)
  5. dry with materialThe combined extracts were dried (Na2SO4 /K2CO3)
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-f46f420f079f4a459b52e7d8a6d35d06
출처 데이터셋
uspto-grants-1982_04
특허 번호
US04327092

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