5-Chloro-2-hydroxybenzamide → 5-Chloro-2-[(6,7-dimethoxy-4-quinolyl)oxy]benzamide

HRID 228638

반응식

HRID 228638 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([OH:26])=[C:21]([CH:25]=1)[C:22]([NH2:24])=[O:23]>CN(C)C1C=CN=CC=1.ClC1C=CC=CC=1Cl>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([O:26][C:2]2[C:11]3[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=3)[N:5]=[CH:4][CH:3]=2)=[C:21]([CH:25]=1)[C:22]([NH2:24])=[O:23]

참가 물질

5

반응물 2

HCID 3480945-Chloro-2-hydroxybenzamideHCID 4596104-Chloro-6,7-dimethoxyquinoline

생성물 1

HCID 577563635-Chloro-2-[(6,7-dimethoxy-4-quinolyl)oxy]benzamide수율 165.2%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 72391,2-Dichlorobenzene용매

반응 조건

온도
120 °C

실험 절차

4-Chloro-6,7-dimethoxyquinoline (100 mg), 5-chloro-2-hydroxybenzamide (343 mg), and 4-dimethylaminopyridine (244 mg) were suspended in o-dichlorobenzene (1 ml), and the suspension was stirred at 120° C. overnight. The reaction solution was cooled to room temperature, and the solvent was removed therefrom by distillation under the reduced pressure. The residue was purified by column chromatography using acetone-hexane to give the title compound (265 mg, yield 100%).

후처리

  1. temperatureThe reaction solution was cooled to room temperature
  2. customthe solvent was removed
  3. distillationby distillation under the reduced pressure
  4. customThe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-6953a73f3758450097841db38d2bbb6c
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

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