Acetic Acid → N-(3-formyl-2-methylphenyl)acetamide

반응식

[CH3:1][C:2]1[C:9]([NH2:10])=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#N.[C:11](OC(=O)C)(=[O:13])[CH3:12].C(O)(=[O:20])C>>[CH3:1][C:2]1[C:9]([NH:10][C:11](=[O:13])[CH3:12])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:20]

참가 물질

반응물 3

HCID 176Acetic Acid

HCID 7918Acetic Anhydride

HCID 2548423-Amino-2-methylbenzonitrile

생성물 1

HCID 20462526N-(3-formyl-2-methylphenyl)acetamide

실험 절차

39g (0.3 mole) of 2-methyl-3-amino-benzonitrile were dissolved in 75 ml of acetic acid, 30 ml (0.3 mole) of acetic anhydride were added, the mixture was heated with reflux for 5 minutes, and cooled. The solid obtained was filtered off and the evaporation of the solent furnished an additional quantity of solid which was added to the preceding one. After recrystallisation of the whole from toluene, 44 g (95%) of colorless flakes were obtained, with a melting point of 160° C. l

후처리

temperaturethe mixture was heated
temperaturewith reflux for 5 minutes
temperaturecooled
customThe solid obtained
filtrationwas filtered off
customthe evaporation of the
customsolent furnished an additional quantity of solid which
additionwas added to the preceding one
customAfter recrystallisation of the whole from toluene, 44 g (95%) of colorless flakes
customwere obtained, with a melting point of 160° C. l

출처 및 근거

ORD 기록: ord-4e54882d31324ec0ac58cc74ee3f731a
출처 데이터셋: uspto-grants-1981_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04266060

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