Hydrogen Bromide → 4-[4-(4-Aminophenyl)piperazin-1-yl]phenol

HRID 2286561

반응식

HRID 2286561 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.Br>O>[NH2:21][C:18]1[CH:17]=[CH:16][C:15]([N:12]2[CH2:13][CH2:14][N:9]([C:6]3[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=3)[CH2:10][CH2:11]2)=[CH:20][CH:19]=1

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 154406Benzenamine, 4-(4-(4-methoxyphenyl)-1-piperazinyl)-

생성물 1

HCID 102210654-[4-(4-Aminophenyl)piperazin-1-yl]phenol수율 44%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 30 parts of 4-[4-(4-methoxyphenyl)-1-piperazinyl]benzenamine and 300 parts of a hydrobromic acid solution 48% in water is stirred and refluxed for 10 days. The reaction mixture is evaporated and the residue is alkalized with sodium hydroxide. The mixture is filtered and the filtrate is acidified with acetic acid. The precipitated product is filtered off and crystallized from 1,4-dioxane, yielding 12 parts (44%) of 4-[4-(4-aminophenyl)-1-piperazinyl]phenol.

후처리

  1. temperaturerefluxed for 10 days
  2. customThe reaction mixture is evaporated
  3. filtrationThe mixture is filtered
  4. filtrationThe precipitated product is filtered off
  5. customcrystallized from 1,4-dioxane

출처 및 근거

ORD 기록
ord-74f03c52f4524d17b188cfeaae012c2d
출처 데이터셋
uspto-grants-1981_05
특허 번호
US04267179

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