Pyridine → HCID 23462409, 화합물

HRID 2286726노트

반응식

HRID 2286726 반응식
C[C:2]1[N:9]2[C:5]([S:6][CH:7]=[CH:8]2)=[N:4][C:3]=1[CH2:10][OH:11].[Cl:12][C:13]1[CH:21]=[CH:20][C:16]([C:17](Cl)=[O:18])=[CH:15][CH:14]=1.N1C=CC=C[CH:23]=1>C(Cl)(Cl)Cl.C(O)(C)C>[ClH:12].[CH3:23][C:8]1[N:9]2[CH:2]=[C:3]([CH2:10][O:11][C:17](=[O:18])[C:16]3[CH:20]=[CH:21][C:13]([Cl:12])=[CH:14][CH:15]=3)[N:4]=[C:5]2[S:6][CH:7]=1

참가 물질

6

반응물 3

HCID 1049PyridineHCID 85014-Chlorobenzoyl chlorideHCID 23462415HCID 23462415, 화합물

생성물 1

HCID 23462409HCID 23462409, 화합물

시약·촉매·용매 2

HCID 3776Isopropanol용매HCID 6212Chloroform용매2회

실험 절차

A solution of 5 g of 5-methyl-6-hydroxymethyl-imidazo-(2,1-b)thiazole in 100 ml of dry chloroform is dropped at room temperature into a solution of 20 ml of p-chlorobenzoyl chlorine and 12 ml of pyridine in 75 ml of dry chloroform. The solution is stirred for 30 minutes at room temperature and filtered. The filtrate is concentrated under vacuum; the residue obtained is dissolved in isopropanol and a stream of dry hydrogen chloride is bubbled into the solution to yield 6 g of 3-methyl-6-p-chlorobenzoyloxymethyl-imidazo-(2,1-b)thiazole hydrochloride; m.p. 198°-199°.

후처리

  1. filtrationfiltered
  2. concentrationThe filtrate is concentrated under vacuum
  3. customthe residue obtained
  4. customa stream of dry hydrogen chloride is bubbled into the solution

출처 및 근거

ORD 기록
ord-efff772f36774f189303e134455d81a4
출처 데이터셋
uspto-grants-1981_05
특허 번호
US04267339

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