Thionyl Chloride → HCID 12874108, 화합물
반응식
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[S:7][CH:8]=[C:9]([CH2:12]O)[C:10]=1[Cl:11]>C(Cl)(Cl)Cl>[Cl:5][C:6]1[S:7][CH:8]=[C:9]([CH2:12][Cl:3])[C:10]=1[Cl:11]참가 물질
4
반응 조건
- 온도
- 10 °C
실험 절차
A mixtures of 357 g of thionyl chloride and 150 ml of chloroform is placed in a 1 liter flask and cooled to 10° C. At 10° to 15° C. and over a period of 35 minutes, a solution of 238 g of 2,3-dichloro-4-hydroxymethylthiophene in 350 ml of chloroform is added. After the exothermic reaction has subsided, the solution is stirred for 1 hour at 30° C., concentrated under reduced pressure and, after a small amount of triethylamine has been added, purified by distillation at 66° to 69° C./0.2 mbar. The yield is 192 g, equivalent to 70% of theory.
후처리
- customAfter the exothermic reaction
- concentrationconcentrated under reduced pressure
- additionafter a small amount of triethylamine has been added
- distillationpurified by distillation at 66° to 69° C./0.2 mbar
출처 및 근거
- ORD 기록
- ord-435b179b4a3e4365b4b7809709c002a1
- 출처 데이터셋
- uspto-grants-1981_05
- 특허 번호
- US04268506
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