Hydrochloric Acid → 3-[5-tert-Butyl-3-isoxazolyl]-4-hydroxy-1-methyl-2-imidazolidinone

HRID 2287056노트

반응식

HRID 2287056 반응식
[CH3:1][C:2]([C:5]1[O:9][N:8]=[C:7]([NH:10][C:11](=[O:20])[N:12]([CH2:14][CH:15](OC)[O:16]C)[CH3:13])[CH:6]=1)([CH3:4])[CH3:3].Cl>O>[CH3:1][C:2]([C:5]1[O:9][N:8]=[C:7]([N:10]2[CH:15]([OH:16])[CH2:14][N:12]([CH3:13])[C:11]2=[O:20])[CH:6]=1)([CH3:4])[CH3:3]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 12918839HCID 12918839, 화합물

생성물 1

HCID 1569093-[5-tert-Butyl-3-isoxazolyl]-4-hydroxy-1-methyl-2-imidazolidinone수율 87.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A round bottom flask was charged with 2.6 grams of the 3-[5-(1,1-dimethylethyl)-3-isoxazoly]-1-methyl-(2,2-dimethoxyethyl)urea (prepared above), 150 milliliters of water and 1.5 milliliters of concentrated hydrochloric acid (HCl). The resulting mixture was heated until one phase formed, and crystals coated out on the sides of the flask and cooled; and the scrapings of the crystals and the solution were filtered. The crystalline precipitate was washed twice with separate portions of H2O, and then air dried to yield 1.9 grams of white crystals of 3-[5-(1,1-dimethylethyl-3-isoxazolyl]-1-methyl-4-hydroxy-2-imidazolidinone. M.P. 173°-177° C., IR spectra (mull.) bands at 3400, 3140, 1700, and 1590 cm-1.

후처리

  1. temperatureThe resulting mixture was heated until one phase
  2. customformed
  3. temperaturecooled
  4. filtrationand the scrapings of the crystals and the solution were filtered
  5. washThe crystalline precipitate was washed twice with separate portions of H2O
  6. customair dried

출처 및 근거

ORD 기록
ord-c362994990f241ed87af13b52630c8f8
출처 데이터셋
uspto-grants-1981_05
특허 번호
US04268679

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