Hydrogen Bromide → 4-(2-methyl-1H-imidazol-1-yl)phenol monohydrobromide

반응식

C[O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH:13]=[CH:12][N:11]=[C:10]2[CH3:14])=[CH:5][CH:4]=1.[BrH:15]>>[BrH:15].[CH3:14][C:10]1[N:9]([C:6]2[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=2)[CH:13]=[CH:12][N:11]=1

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 127971081-(4-methoxyphenyl)-2-methyl-1H-imidazole

생성물 1

HCID 234610084-(2-methyl-1H-imidazol-1-yl)phenol monohydrobromide수율 69%

실험 절차

A mixture of 4 parts of 1-(4-methoxyphenyl)-2-methyl-1H-imidazole and 37.5 parts of hydrobromic acid solution 48% is stirred and refluxed overnight. After cooling, the reaction mixture is evaporated. The residue is triturated in a mixture of 2-propanone and 2,2'-oxybispropane. The product is filtered off and crystallized from a mixture of ethanol and 2,2'-oxybispropane, yielding 3.8 parts (69%) of 4-(2-methyl-1H-imidazol-1-yl)phenol monohydrobromide; mp. 181°-205° C.

후처리

temperaturerefluxed overnight
temperatureAfter cooling
customthe reaction mixture is evaporated
customThe residue is triturated in a mixture of 2-propanone and 2,2'-oxybispropane
filtrationThe product is filtered off
customcrystallized from a mixture of ethanol and 2,2'-oxybispropane

출처 및 근거

ORD 기록: ord-422831d488964b5f95b79038feacfd3c
출처 데이터셋: uspto-grants-1981_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04268680

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