Bromine → 2-Bromo-5,6-dimethoxy-3-methylbenzene-1,4-diol

HRID 2287258노트

반응식

HRID 2287258 반응식
[Br:1]Br.[CH3:3][O:4][C:5]1[C:11]([O:12][CH3:13])=[C:10]([OH:14])[C:9]([CH3:15])=[CH:8][C:6]=1[OH:7]>C(Cl)(Cl)Cl>[CH3:3][O:4][C:5]1[C:11]([O:12][CH3:13])=[C:10]([OH:14])[C:9]([CH3:15])=[C:8]([Br:1])[C:6]=1[OH:7]

참가 물질

4

반응물 2

HCID 24408BromineHCID 111830272,3-Dimethoxy-5-methyl-1,4-benzenediol

생성물 1

HCID 127215532-Bromo-5,6-dimethoxy-3-methylbenzene-1,4-diol수율 100.7%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

A solution of 39.5 g of bromine in 70 ml of chloroform was added dropwise at about 5° C. to a solution of 46.0 g of 2,3-dimethoxy-5-methylhydroquinone in 500 ml of chloroform, under a nitrogen atmosphere. Stirring was continued at the same temperature for 3 hours, and then the reaction mixture was washed with water until the washings were colorless. The organic layer was dried over magnesium sulfate, and the solvent was distilled off under reduced pressure to provide 65.5 g of 2,3-dimethoxy-5-methyl-6-bromohydroquinone.

후처리

  1. washthe reaction mixture was washed with water until the washings
  2. dry with materialThe organic layer was dried over magnesium sulfate
  3. distillationthe solvent was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-883910633b4440c3995129d0be420811
출처 데이터셋
uspto-grants-1981_05
특허 번호
US04270003

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