Ammonium Acetate → 5,6-Dimethyl-2-phenyl-pyridin-3-ol

HRID 228809

반응식

HRID 228809 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=O)[O:5][C:6]=1[CH3:7].C([O-])(=O)C.[NH4+:20]>>[CH3:1][C:2]1[CH:3]=[C:4]([OH:5])[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:20][C:6]=1[CH3:7]

참가 물질

3

반응물 2

HCID 517165Ammonium AcetateHCID 23078263(4,5-Dimethylfuran-2-yl)-phenyl-methanone

생성물 1

HCID 230783805,6-Dimethyl-2-phenyl-pyridin-3-ol수율 16,079.1%

반응 조건

온도
250 °C

실험 절차

(4,5-Dimethylfuran-2-yl)-phenyl-methanone (1 g) and ammonium acetate (910 mg) were placed in a sealed tube, and the mixture was stirred at 250° C. for 10 hr. The reaction solution was cooled to room temperature, the solvent was then removed by distillation under the reduced pressure, and the residue was purified by column chromatography using hexane-ethyl acetate to give 5,6-dimethyl-2-phenyl-pyridin-3-ol (160 g, yield 16%).

후처리

  1. temperatureThe reaction solution was cooled to room temperature
  2. customthe solvent was then removed by distillation under the reduced pressure
  3. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-09edd896e4074eec884e88b7cdbc2141
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

연결된 노트

불러오는 중…