(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)-methanol → (4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)methanone

HRID 228818

반응식

HRID 228818 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=2)[OH:9])[O:5][C:6]=1[CH3:7]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[N:11]=2)=[O:9])[O:5][C:6]=1[CH3:7]

참가 물질

4

반응물 1

HCID 23078353(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)-methanol

생성물 1

HCID 23078390(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)methanone수율 58.8%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매2회HCID 6212Chloroform용매

실험 절차

(4,5-Dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)-methanol (1.4 g) was dissolved in chloroform (30 ml) to prepare a solution. Manganese dioxide (5.7 g) was added to the solution, and the mixture was stirred at room temperature overnight. Further, manganese dioxide (1.8 g) was then added thereto, and the mixture was stirred overnight. The reaction solution was filtered through Celite. The solvent was removed from the filtrate by distillation under the reduced pressure to give (4,5-dimethylfuran-2-yl)-(6-methyl-pyridin-2-yl)-methanone (815 mg, yield 58%).

후처리

  1. customto prepare a solution
  2. stirringthe mixture was stirred overnight
  3. filtrationThe reaction solution was filtered through Celite
  4. customThe solvent was removed from the filtrate by distillation under the reduced pressure

출처 및 근거

ORD 기록
ord-6ab18d8b261b491b95b95d5380da68f3
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

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