(4,5-Dimethylfuran-2-yl)-(4-methyl-pyridin-2-yl)-methanol → (4,5-Dimethylfuran-2-yl)-(4-methyl-pyridin-2-yl)-methanone

HRID 228826

반응식

HRID 228826 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]([C:10]2[CH:15]=[C:14]([CH3:16])[CH:13]=[CH:12][N:11]=2)[OH:9])[O:5][C:6]=1[CH3:7]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[C:14]([CH3:16])[CH:13]=[CH:12][N:11]=2)=[O:9])[O:5][C:6]=1[CH3:7]

참가 물질

4

반응물 1

HCID 23078475(4,5-Dimethylfuran-2-yl)-(4-methyl-pyridin-2-yl)-methanol

생성물 1

HCID 23078347(4,5-Dimethylfuran-2-yl)-(4-methyl-pyridin-2-yl)-methanone수율 77.4%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매2회HCID 6212Chloroform용매

실험 절차

(4,5-Dimethylfuran-2-yl)-(4-methyl-pyridin-2-yl)-methanol (900 mg) was dissolved in chloroform (20 ml) to prepare a solution. Manganese dioxide (3.6 g) was added to the solution, and the mixture was stirred at room temperature overnight. Further, manganese dioxide (1.8 g) was then added to the reaction solution, and the mixture was stirred at room temperature for 5 hr. The reaction solution was filtered through Celite, and the solvent was removed from the filtrate by distillation under the reduced pressure, and the residue was purified by column chromatography using hexane-ethyl acetate to give (4,5-dimethylfuran-2-yl)-(4-methyl-pyridin-2-yl)-methanone (690 mg, yield 77%).

후처리

  1. customto prepare a solution
  2. stirringthe mixture was stirred at room temperature for 5 hr
  3. filtrationThe reaction solution was filtered through Celite
  4. customthe solvent was removed from the filtrate by distillation under the reduced pressure
  5. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-b79a5c0abf3748e197e2d1d621430bd9
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

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