Ethyl 6-methoxy-7-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylate → 6-Methoxy-7-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

HRID 228864노트

반응식

HRID 228864 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[NH:9][CH:8]=[C:7]([C:14]([O:16]CC)=[O:15])[C:6]2=[O:19]>[OH-].[Na+]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[NH:9][CH:8]=[C:7]([C:14]([OH:16])=[O:15])[C:6]2=[O:19]

참가 물질

3

반응물 1

HCID 12369042Ethyl 6-methoxy-7-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylate

생성물 1

HCID 123690366-Methoxy-7-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid수율 98%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

Ethyl 6-methoxy-7-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylate (25.5 g) was suspended in a 2 M aqueous sodium hydroxide solution (250 ml), and the mixture was heated under reflux for 4 hr. The reaction solution was cooled to room temperature, the aqueous layer was then washed with chloroform and was neutralized with dilute hydrochloric acid. The precipitated crystal was collected by filtration and was washed with water, isopropanol, and hexane in that order to give 6-methoxy-7-methyl-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (22.1 g, yield 98%).

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 4 hr
  3. washthe aqueous layer was then washed with chloroform
  4. filtrationThe precipitated crystal was collected by filtration
  5. washwas washed with water, isopropanol, and hexane in that order

출처 및 근거

ORD 기록
ord-a435b2078c944f388bd4f04110d56ab9
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

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