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1,2-Dichlorobenzene → 4-(5-Chloro-7-methyl-quinolin-6-yloxy)-6,7-dimethoxy-quinoline

HRID 228881
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HRID 228881 반응식
Br[C:2]1[C:11]([OH:12])=[C:10]([CH3:13])[CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2.Cl[C:15]1[C:24]2[C:19](=[CH:20][C:21]([O:27][CH3:28])=[C:22]([O:25][CH3:26])[CH:23]=2)[N:18]=[CH:17][CH:16]=1.[Cl:29]C1C=CC=CC=1Cl>CN(C)C1C=CN=CC=1>[Cl:29][C:2]1[C:11]([O:12][C:15]2[C:24]3[C:19](=[CH:20][C:21]([O:27][CH3:28])=[C:22]([O:25][CH3:26])[CH:23]=3)[N:18]=[CH:17][CH:16]=2)=[C:10]([CH3:13])[CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][CH:6]=[N:7]2
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 72391,2-DichlorobenzeneHCID 4596104-Chloro-6,7-dimethoxyquinolineHCID 230783095-Bromo-6-hydroxy-7-methyl-quinoline

생성물 1

HCID 230783154-(5-Chloro-7-methyl-quinolin-6-yloxy)-6,7-dimethoxy-quinoline수율 10%

시약·촉매·용매 1

HCID 142844-(Dimethylamino)pyridine촉매

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온도
140 °C

실험 절차

5-Bromo-6-hydroxy-7-methyl-quinoline (110 mg), 4-chloro-6,7-dimethoxyquinoline (330 mg), and 4-dimethylaminopyridine (240 mg) were suspended in o-dichlorobenzene (10 ml), and the mixture was stirred at 140° C. for 6 hr. The reaction solution was cooled to room temperature, and the solvent was removed therefrom by distillation under the reduced pressure. The residue was purified by thin layer chromatography using acetone-chloroform to give the title compound (19 mg, yield 10%).

후처리

  1. temperatureThe reaction solution was cooled to room temperature
  2. customthe solvent was removed
  3. distillationby distillation under the reduced pressure
  4. customThe residue was purified by thin layer chromatography

출처 및 근거

ORD 기록
ord-c6d4e4992f244669b0443c109f795087
출처 데이터셋
uspto-grants-2009_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07560558B2

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