Ethanol → 4-(4-Ethoxymethyl-5-phenyl-oxazol-2-yl)-piperidine

HRID 2288958노트

반응식

HRID 2288958 반응식
Cl[CH2:2][C:3]1[N:4]=[C:5]([CH:14]2[CH2:19][CH2:18][N:17](C(=O)C)[CH2:16][CH2:15]2)[O:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[OH-].[Na+].[CH2:25]([OH:27])[CH3:26]>O>[CH2:25]([O:27][CH2:2][C:3]1[N:4]=[C:5]([CH:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[O:6][C:7]=1[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[CH3:26]

참가 물질

5

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 187004361-[4-(4-Chloromethyl-5-phenyl-oxazol-2-yl)-piperidin-1-yl]ethanone

생성물 1

HCID 187004234-(4-Ethoxymethyl-5-phenyl-oxazol-2-yl)-piperidine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 1-[4-(4 -chloromethyl-5-phenyl-oxazol-2-yl)-piperidin-1-yl]-ethanone (0.200 g, 0.627 mmol), prepared as in intermediate 3B, in ethanol (4.5 ml) is treated with a solution of NaOH (0.501 g, 12.55 mmol) in water (1/.5 ml). The reaction mixture is heated to 75 C for 48 hours, concentrated, and the residue partitioned between EtOAc and water. The aqueous phase is washed with EtOAc (twice). The organic phases are combined and washed with saturated brine, dried (Na2SO4) and concentrated to afford the title compound as a light orange oil.

후처리

  1. temperatureThe reaction mixture is heated to 75 C for 48 hours
  2. concentrationconcentrated
  3. customthe residue partitioned between EtOAc and water
  4. washThe aqueous phase is washed with EtOAc (twice)
  5. washwashed with saturated brine
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4ad37e2424214caf818e7dc38e70c827
출처 데이터셋
uspto-grants-2000_07
특허 번호
US06090825

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