Potassium bisulfate → tert-Butyl (4-oxopentyl)carbamate

HRID 2289158노트

반응식

HRID 2289158 반응식
[C:1]([O:5][C:6](=[O:17])[NH:7][CH2:8][CH2:9][CH2:10][C:11](=[O:16])N(OC)C)([CH3:4])([CH3:3])[CH3:2].[CH3:18][Mg]Br.OS([O-])(=O)=O.[K+]>C1COCC1>[C:1]([O:5][C:6](=[O:17])[NH:7][CH2:8][CH2:9][CH2:10][C:11](=[O:16])[CH3:18])([CH3:2])([CH3:3])[CH3:4]

참가 물질

5

반응물 3

HCID 516920Potassium bisulfateHCID 23112516tert-butyl N-(3-(methoxy(methyl)carbamoyl)propyl)carbamateHCID 178418573HCID 178418573, 화합물

생성물 1

HCID 21478928tert-Butyl (4-oxopentyl)carbamate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of 1-3 (10.0 g, 40.5 mmol) and THF (200 ml) at 0° C. was added methyl magnesium bromide (27.0 ml, 91.0 mmol; 3M in ether) dropwise over 20 minutes. Mter 2.0 hours, 10% KHSO4 was added slowly. The mixture was extracted with EtOAc. The organic portion was washed with saturated NaHCO3, brine, and dried over MgSO4. Evaporative removal of the solvent gave 1-4 as a colorless oil.

후처리

  1. extractionThe mixture was extracted with EtOAc
  2. washThe organic portion was washed with saturated NaHCO3, brine
  3. dry with materialdried over MgSO4
  4. customEvaporative removal of the solvent

출처 및 근거

ORD 기록
ord-696f3cf5a37a4ce09e24f18fba1559ba
출처 데이터셋
uspto-grants-2000_07
특허 번호
US06090944

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