Hydrochloric Acid → HCID 24847455, 화합물

HRID 2289418

반응식

HRID 2289418 반응식
[ClH:1].[CH3:2][C@@:3]([C:13]([OH:15])=[O:14])([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)[NH2:4].[CH3:16]O>>[ClH:1].[CH3:16][O:14][C:13](=[O:15])[C@:3]([CH3:2])([CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1)[NH2:4]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 441350Metyrosine

생성물 1

HCID 24847455HCID 24847455, 화합물수율 100%

실험 절차

Anhydrous hydrogen chloride was bubbled through a solution of α-methyl-L-tyrosine (1 g, 5.13 mmol) in methanol (100 ml) for a few minutes and the solution stirred at room temeprature for 48 h. The solvent was evaporated in vacuo and the residue freeze dried from a mixture of methanol and water to give the title compound as a white powder (1.28 g, 100%); δH (CD3OD) 7.00 (2H, d, J 8.6 Hz, ArH), 6.78 (2H, d, J 8.6 Hz, ArH), 3.82 (3H, s, CO2CH3), 3.19 (1H, d, J 14.3 Hz, CHAHBAr), 3.01 (1H, d, J 14.3 Hz, CHAHBAr) and 1.59 (3H, s, CCH3); m/z (ES, 27V) 210 (M+ +1).

후처리

  1. customThe solvent was evaporated in vacuo
  2. dry with materialthe residue freeze dried from a mixture of methanol and water

출처 및 근거

ORD 기록
ord-6605b8bf3da4442babab6bcdcbf37ab6
출처 데이터셋
uspto-grants-2000_07
특허 번호
US06093696

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