Hydrochloric Acid → 1-(4-methylpiperazine-1-carbonyl)cyclopentan-1-amine dihydrochloride

HRID 2289827노트

반응식

HRID 2289827 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2([NH:15]C(=O)OC(C)(C)C)[CH2:14][CH2:13][CH2:12][CH2:11]2)=[O:9])[CH2:4][CH2:3]1.[ClH:23]>CCOC(C)=O>[ClH:23].[ClH:23].[NH2:15][C:10]1([C:8]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)=[O:9])[CH2:14][CH2:13][CH2:12][CH2:11]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 18698346HCID 18698346, 화합물

생성물 1

HCID 186982131-(4-methylpiperazine-1-carbonyl)cyclopentan-1-amine dihydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A suspension of tert-butyl 1-[(4-methyl-1-piperazinyl)carbonyl]cyclopentylcarbamate (2.2 g, 7.06 mmol) in EtOAc (120 ml) at 4° C. was saturated with HCl gas, and the reaction then stirred for 4 h. The mixture was azeotroped with EtOAc, then dry Et2O, and dried under vacuum to afford (1-aminocyclopentyl)(4-methyl-1-piperazinyl)methanone dihydrochloride (2.1 g) as a white solid.

후처리

  1. customthe reaction
  2. customThe mixture was azeotroped with EtOAc
  3. dry with materialdry Et2O, and dried under vacuum

출처 및 근거

ORD 기록
ord-ab61e76b0c2e462ba2d15632193aa316
출처 데이터셋
uspto-grants-2000_07
특허 번호
US06093731

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