Ammonia → N-formyl-1-(3-benzyloxyphenyl)ethylamine

HRID 2289877

반응식

HRID 2289877 반응식
[CH:1]([O-:3])=O.[NH4+:4].N.[CH2:6]([O:13][C:14]1[CH:15]=[C:16]([C:20](=O)[CH3:21])[CH:17]=[CH:18][CH:19]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.ClC1C=C(Cl)C=CC=1C(=O)C>C(O)=O>[CH:1]([NH:4][CH:20]([C:16]1[CH:17]=[CH:18][CH:19]=[C:14]([O:13][CH2:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH:15]=1)[CH3:21])=[O:3]

참가 물질

6

반응물 4

HCID 222Ammonia3회HCID 166932',4'-Dichloroacetophenone2회HCID 986891-(3-(Phenylmethoxy)phenyl)ethan-1-oneHCID 2723923Ammonium formate

생성물 1

HCID 18699232N-formyl-1-(3-benzyloxyphenyl)ethylamine

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

In the same manner as in Example 5 except that 405 q of ammonium formate was placed in the reaction vessel, 569 g of 76% formic acid was placed in the pot of the ammonia absorbing tower, 3'-benzyloxyacetophenone and the pot solution of the ammonia absorbing tower were added to the vessel at 2.54 g/min. and 3-6 g/min. respectively over 3 hours in place of 2',4'-dichloroacetophenone at 0.86 g/min. and the pot solution of the ammonia absorbing tower at 0.48 g/min, and the stirring time after addition was 10 hours in place of 7 hours, the reaction and post treatment were carried out to obtain 497 g of crude N-formyl-1-(3-benzyloxyphenyl)ethylamine (the purity: 97.8%) in place of 2',4'-dichloroacetophenone at 0.86 g/min. and the pot solution of the ammonia absorbing tower at 0.48 g/min.

후처리

  1. customthe reaction and post treatment

출처 및 근거

ORD 기록
ord-9d6b901ffee5484bb216185c1421511f
출처 데이터셋
uspto-grants-2000_07
특허 번호
US06093851

연결된 노트

불러오는 중…