Hydrochloric Acid → HCID 20232116, 화합물

HRID 2290362노트

반응식

HRID 2290362 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[N:12][C:11]([NH:14][NH2:15])=[N:10][C:9]=2[CH3:16])=[CH:4][CH:3]=1.Cl>C(O)C.[Pd]>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]([CH3:16])[N:10]=[C:11]([NH:14][NH2:15])[NH:12][N:13]=2)=[CH:6][CH:7]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 20232011HCID 20232011, 화합물

생성물 1

HCID 20232116HCID 20232116, 화합물수율 80.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

6-(4-Chlorophenyl)-3-hydrazino-5-methyl-1,2,4-triazine (4.36 g) was dissolved in ethanol (70 ml) containing anhydrous hydrogen chloride, and then hydrogenated over 5% palladium on carbon (0.73 g) under atmospheric pressure at room temperature. After the theoretical amount of hydrogen gas was absorbed, the catalyst was filtered off. The filtrate was evaporated under reduced pressure to give a residual solid, which was recrystallized from diluted hydrochloric acid to give colorless crystals of 6-(4-chlorophenyl)-3-hydrazino-5-methyl-2,5-dihydro-1,2,4-triazine hydrochloride (2.04 g), m.p. 207°~208° C.

후처리

  1. customAfter the theoretical amount of hydrogen gas was absorbed
  2. filtrationthe catalyst was filtered off
  3. customThe filtrate was evaporated under reduced pressure
  4. customto give a residual solid, which
  5. customwas recrystallized from diluted hydrochloric acid

출처 및 근거

ORD 기록
ord-23e2b66d3e65456a8bdf8578268ebb46
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04616014

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