Potassium Carbonate → Methyl 4-[1-(benzenesulphonyl)-piperazin-4-ylmethyl]-benzoate

HRID 2290451

반응식

HRID 2290451 반응식
Br[CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][CH:4]=1.[C:13]1([S:19]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)(=[O:21])=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[C:13]1([S:19]([N:22]2[CH2:27][CH2:26][N:25]([CH2:2][C:3]3[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][CH:4]=3)[CH2:24][CH2:23]2)(=[O:21])=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 256687Methyl 4-(bromomethyl)benzoateHCID 8087121-(Benzenesulfonyl)piperazine

생성물 1

HCID 8743532Methyl 4-[1-(benzenesulphonyl)-piperazin-4-ylmethyl]-benzoate

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A mixture of 11.5 g. (50 mmole) methyl 4-bromomethylbenzoate, 11.3 g. (50 mmole) 1-benzenesulphonylpiperazine, 6.91 g. (50 mmole) powdered potassium carbonate and 100 ml. butan-2-one is maintained at reflux temperature for 20 hours, then suction filtered while hot and the filtrate evaporated. After cooling, the product is filtered off with suction and recrystallised from methanol to give 11.6 g. (62% of theory) of the desired product; m.p. 145°-146° C.

후처리

  1. additionA mixture of 11.5 g
  2. temperatureat reflux temperature for 20 hours
  3. filtrationsuction filtered while hot and the filtrate
  4. customevaporated
  5. temperatureAfter cooling
  6. filtrationthe product is filtered off with suction
  7. customrecrystallised from methanol
  8. customto give 11.6 g

출처 및 근거

ORD 기록
ord-3b0bc9d052a841da8602a09a7a0a9eea
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04616086

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