Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Methyl 4-[1-(benzenesulphonyl)-piperazin-4-ylmethyl]-benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Methyl 4-(bromomethyl)benzoate | HCID 256687 | — |
| 반응물 | 1-(Benzenesulfonyl)piperazine | HCID 808712 | — |
| 용매 | Methyl Ethyl Ketone | HCID 6569 | — |
| 생성물 | Methyl 4-[1-(benzenesulphonyl)-piperazin-4-ylmethyl]-benzoate | HCID 8743532 | — |
반응 단계
A mixture of 11.5 g. (50 mmole) methyl 4-bromomethylbenzoate, 11.3 g. (50 mmole) 1-benzenesulphonylpiperazine, 6.91 g. (50 mmole) powdered potassium carbonate and 100 ml. butan-2-one is maintained at reflux temperature for 20 hours, then suction filtered while hot and the filtrate evaporated. After cooling, the product is filtered off with suction and recrystallised from methanol to give 11.6 g. (62% of theory) of the desired product; m.p. 145°-146° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04616086 |
| 출처 데이터셋 | uspto-grants-1986_10 |
| ORD ID | ord-3b0bc9d052a841da8602a09a7a0a9eea |
| 출처 메모 | uspto-grants-1986_10 |