(4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanol → (4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanone

HRID 229049

반응식

HRID 229049 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]([C:10]2[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][N:11]=2)[OH:9])[O:5][C:6]=1[CH3:7]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[C:15]([CH3:16])=[CH:14][CH:13]=[CH:12][N:11]=2)=[O:9])[O:5][C:6]=1[CH3:7]

참가 물질

4

반응물 1

HCID 23078465(4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanol

생성물 1

HCID 23078529(4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanone수율 81.1%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

(4,5-Dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanol (1.17 g) was dissolved in chloroform (30 ml) to prepare a solution. Manganese dioxide (4.69 g) was added to the solution, and the mixture was stirred at room temperature overnight. The reaction solution was filtered through Celite, and the solvent was removed from the filtrate by distillation under the reduced pressure to give (4,5-dimethylfuran-2-yl)-(3-methylpyridin-2-yl)-methanone (940 mg, yield 81%).

후처리

  1. customto prepare a solution
  2. filtrationThe reaction solution was filtered through Celite
  3. customthe solvent was removed from the filtrate by distillation under the reduced pressure

출처 및 근거

ORD 기록
ord-d541dd2f8c2b40be824318bccb382ad9
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

연결된 노트

불러오는 중…