Water → 2-Fluoro-1-(methylsulfonyl)-4-nitrobenzene

HRID 22907

반응식

HRID 22907 반응식
[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[CH3:12][S:13]([O-:15])=[O:14].[Na+].O>CS(C)=O>[F:1][C:2]1[CH:3]=[C:4]([N+:9]([O-:11])=[O:10])[CH:5]=[CH:6][C:7]=1[S:13]([CH3:12])(=[O:15])=[O:14]

참가 물질

5

반응물 3

HCID 962WaterHCID 1230531,2-Difluoro-4-nitrobenzeneHCID 2733271Sodium methanesulfinate

생성물 1

HCID 223167812-Fluoro-1-(methylsulfonyl)-4-nitrobenzene수율 79%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
60 °C

실험 절차

8 g of 3,4-difluoronitrobenzene and 1.01 eq of sodium methanesulfinate (95%) was dissolved in 10 ml of DMSO. The solution was stirred at 60° C. for 3 hours. When the reaction was completed, the solution was added to 100 ml of water to form pale yellow solid, followed by filtration and washing with 50 ml of cool water and 30 ml of n-hexane separately to give 8.8 g of the title compound as a pale yellow solid (yield 79%).

후처리

  1. customto form pale yellow solid
  2. filtrationfollowed by filtration
  3. washwashing with 50 ml of cool water and 30 ml of n-hexane separately

출처 및 근거

ORD 기록
ord-d65540f051e14807a858c381dcb08832
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06849652B1

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