Methyl Isocyanate → HCID 13690936, 화합물

HRID 2290988노트

반응식

HRID 2290988 반응식
[NH2:1][C:2]1[N:3]=[N:4][C:5]([Cl:12])=[C:6]([C:8]([CH3:11])([CH3:10])[CH3:9])[CH:7]=1.[CH3:13][N:14]=[C:15]=[O:16]>C(Cl)Cl.C(N(CC)CC)C>[Cl:12][C:5]1[N:4]=[N:3][C:2]([NH:1][C:15]([NH:14][CH3:13])=[O:16])=[CH:7][C:6]=1[C:8]([CH3:9])([CH3:11])[CH3:10]

참가 물질

5

반응물 2

HCID 12228Methyl Isocyanate2회HCID 1637143-Pyridazinamine, 6-chloro-5-(1,1-dimethylethyl)-

생성물 1

HCID 13690936HCID 13690936, 화합물

시약·촉매·용매 2

HCID 8471Triethylamine촉매HCID 6344Dichloromethane용매2회

실험 절차

To a mixture of 1.3 g of (0.007 mole) of 3-amino-6-chloro-5-(1,1-dimethylethyl)pyridazine in 65 ml of methylene chloride was added one drop of triethylamine and 0.8 g (0.014 mole, 2.0 equivalents) of methyl isocyanate. The mixture was stirred at room temperature for about 18 hours. Additional methyl isocyanate (0.8 g, 0.140 mole, 2.0 equivalents) was added and about 3 hours later, the solution was diluted to 400 ml using methylene chloride. The solution was washed with four 40-ml portions of 1.0N hydrochloric acid and 50 ml of water, and was then dried with magnesium sulfate.

후처리

  1. additionthe solution was diluted to 400 ml
  2. washThe solution was washed with four 40-ml portions of 1.0N hydrochloric acid and 50 ml of water
  3. dry with materialwas then dried with magnesium sulfate

출처 및 근거

ORD 기록
ord-a1a9d47bb9404b8085f177c37bb72548
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04619686

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